Background: Monocytic human leukocyte antigen DR (mHLA-DR) expression levels have been reported to be a marker of immunosuppression and predictors of sepsis and death. There is, however, insufficient data regarding mHLA-DR monitoring in young infants after cardiopulmonary bypass. Our aim was to investigate the kinetics of mHLA-DR expression and to determine whether the rate-DR mHLA healthcare-related infections associated (HAI) after cardiopulmonary bypass in young infants.


Methods: mHLA-DR levels were analyzed by flow cytometry using standard methods in 49 infants (<3 months) with congenital heart disease before and after cardiopulmonary bypass. Results expressed as the number of anti-HLA-DR antibodies per cell (AB / c).


Results: Expression of postoperative mHLA-DR decreased in all infants. Eleven patients (22%) developed HAI and 4 patients (8%) died during the 30-day follow-up. MHLA-DR expression was significantly lowered on postoperative day 4 in the HAI group compared with those without HAI (3768 AB / c [1.938 to 6.144] vs 13 230 AB / c [6.152 to 19.130]; p = 0.0142). Although the expression mHLA-DR was associated with the severity of postoperative, mHLA-DR ≤ 4500 AB / c in the first 72 hours among patients with the severity of postoperative higher (lung artificial and / or corticoids and / or delayed closure of the sternum ) is associated with the occurrence of HAI in the univariate analysis (OR = 6.3, 95% CI 1.0, 38.7; p = 0.037).


Conclusion: Cardiopulmonary bypass induces a substantial decrease in mHLA-DR expression in young infants. Among patients with the severity of postoperative higher, the low level of mHLA-DR in the early postoperative period is associated with the development of HAI.

Monocytic human leukocyte antigen DR expression in young infants undergoing cardiopulmonary bypass
Monocytic human leukocyte antigen DR expression in young infants undergoing cardiopulmonary bypass

In Silico Prediction of Human Leukocyte Antigen (HLA) Class II Binding of Hepatitis B Virus (HBV) Peptide in Botswana

hepatitis B virus (HBV) is a major cause of liver-related malignancies worldwide, and there is no effective cure for chronic HBV infection (CHB) today. a strong immune response caused by T cells associated with HBV clearance during the acute infection;

However, the repertoire of epitopes (epi) presented by major histocompatibility complexes (MHCs) to obtain this response in various African populations is not well understood. In silico approach used to map and investigate the 15-mer peptide HBV restricted 9 HLA class II alleles with a high population coverage in Botswana.

The sequence of the 44 HBV genotype and gene 48 genotype D surface (Pres / S) of Botswana used. From 1819 binding epi predicted, 20.2% is a strong binder (SB), and no epi allegedly binding to all 9 alleles indicates that the multi-epitope, genotype-based, population-based vaccine will be effective against HBV infection as opposed to the previously proposed broad potential epitope-vaccine is assumed to work for all alleles. In total, there are 297 unique epi predictable than 3 protein and between, S epi region has the highest number (n = 186).

Epitope-density (Depi) between genotypes A and D are similar. A number of mutations that inhibit the binding of HLA-peptide were observed. We also identify the specific peptide antigens and genotypes with characteristics that are very suitable for the development of sensitive diagnostic kit. This study identified candidate peptides that can be used to develop a multi-epitope vaccines and diagnostic kits are highly sensitive to the HBV infection in African populations.

Anti-HLA-DR APC

1A-690-T025 25 tests
EUR 140

Anti-HLA-DR APC

1A-690-T100 100 tests
EUR 240

Anti-HLA-DR/DP APC

1A-296-T025 25 tests
EUR 140

Anti-HLA-DR/DP APC

1A-296-T100 100 tests
EUR 240

Anti-HLA-DR APC-Cy7

T4-690-T025 25 tests
EUR 154

Anti-HLA-DR APC-Cy7

T4-690-T100 100 tests
EUR 268

HLA-DR+DP Antibody (APC)

abx140299-100tests 100 tests
EUR 481

Mouse Anti Human Hla Dr Monoclonal Antibody,APC

DMABT-48803MH 100 TEST
EUR 767

anti-HLA-DR

YF-PA12351 50 ug
EUR 363
Description: Mouse polyclonal to HLA-DR

anti-HLA-DR

YF-PA12352 50 ul
EUR 363
Description: Mouse polyclonal to HLA-DR

anti-HLA-DR

YF-PA12353 50 ug
EUR 363
Description: Mouse polyclonal to HLA-DR

anti-HLA-DR

YF-PA12354 100 ul
EUR 403
Description: Rabbit polyclonal to HLA-DR

anti-HLA-DR

YF-PA12355 100 ug
EUR 403
Description: Rabbit polyclonal to HLA-DR

anti-HLA-DR

520-A-01mg 0,1 mg
EUR 267.5
Description: anti-HLA-DR

anti-HLA-DR

520-A-1000ug 1000 ug
EUR 1282.5
Description: anti-HLA-DR

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (APC)

abx200527-100tests 100 tests
EUR 634

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (APC)

abx140295-100tests 100 tests
EUR 481

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (APC)

abx140306-100tests 100 tests
EUR 481

Anti-HLA/DR antibody

STJ16100046 100 µg
EUR 406

Anti-HLA-DR/HLA-DRA Antibody

A01195 100ug/vial
EUR 334

Anti-HLA-DR Antibody [L243], APC-Cy7-100Tests

QAB86-APC7-100Tests 100Tests
EUR 403

Anti-HLA-DR Antibody [L243], APC-Cy7-25Tests

QAB86-APC7-25Tests 25Tests
EUR 225

LAMBDA Antibody (APC-C750)

abx200545-100tests 100 tests
EUR 1135

CPA Antibody (APC-C750)

abx201108-100tests 100 tests
EUR 913

Anti-HLA-DR Purified

11-241-C025 0.025 mg
EUR 104

Anti-HLA-DR Purified

11-241-C100 0.1 mg
EUR 167

Anti-HLA-DR Purified

11-474-C025 0.025 mg
EUR 104

Anti-HLA-DR Purified

11-474-C100 0.1 mg
EUR 167

Anti-HLA-DR Purified

11-690-C025 0.025 mg
EUR 104

Anti-HLA-DR Purified

11-690-C100 0.1 mg
EUR 167

Anti-HLA-DR FITC

1F-474-T025 25 tests
EUR 122

Anti-HLA-DR FITC

1F-474-T100 100 tests
EUR 204

Anti-HLA-DR FITC

1F-690-T025 25 tests
EUR 122

Anti-HLA-DR FITC

1F-690-T100 100 tests
EUR 204

Anti-HLA-DR PE

1P-474-T025 25 tests
EUR 140

Anti-HLA-DR PE

1P-474-T100 100 tests
EUR 240

Anti-HLA-DR PE

1P-690-T025 25 tests
EUR 140

Anti-HLA-DR PE

1P-690-T100 100 tests
EUR 240

Anti-HLA-DR PerCP

PC-474-T025 25 tests
EUR 140

Anti-HLA-DR PerCP

PC-474-T100 100 tests
EUR 240

Anti-HLA-DR+DP antibody

STJ16100003 100 µg
EUR 406

Anti-HLA-DR antigen antibody

STJ16100045 1 mL
EUR 478

Anti-HLA-DR+DP antibody

STJ16100047 100 µg
EUR 406

Anti-HLA-DR+DP antibody

STJ16100576 100 tests
EUR 524

HLA-DR

HLADRA-100T 100 test
EUR 411.4

HLA-DR

HLADRAC750-100T 100 test
EUR 583

HLA-DR

HLADRB-01MG 100 test
EUR 284

HLA-DR

HLADRCFB-100T 100 test
EUR 388

HLA-DR

HLADRCFB2-100T 100 test
EUR 388

HLA-DR

HLADRF-100T 100 test
EUR 297

HLA-DR

HLADRPE-100T 100 test
EUR 349

HLA-DR

HLADRPP-100T 100 test
EUR 349

HLA-DR

HLADRPP5.5-100T 100 test
EUR 388

HLA-DR

HLADRPP5.52-100T 100 test
EUR 531

HLA-DR

HLADRPU-01MG 0,1 mg
EUR 219

HLA-DR antibody

23013-100ul 100ul
EUR 390

HLA-DR Antibody

48982-100ul 100ul
EUR 333

HLA-DR Antibody

48982-50ul 50ul
EUR 239

Anti-Human HLA-ABC Monoclonal Antibody APC Conjugated, Flow Validated

FC20056-APC 25 Tests, 100 Tests, 200 Tests
EUR 176
Description: Mouse Monoclonal Human HLA-ABC Antibody APC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Leukosialin (CD43) Antibody (APC-C750)

abx200292-100tests 100 tests
EUR 1274

Anti-HLA-DRA/Hla Dr Rabbit Monoclonal Antibody

M01195-2 100ug/vial
EUR 397
Description: Rabbit Monoclonal HLA-DRA/Hla Dr Antibody. Validated in IF, WB and tested in Human, Mouse, Rat.

Mouse Anti Human Hla Dr Monoclonal Antibody

DMABT-48801MH 0.2 mg
EUR 881

Mouse Anti Human Hla Dr Monoclonal Antibody

DMABT-48806MH 0.2 mg
EUR 767

Rat Anti Human Hla Dr Monoclonal Antibody

DMABT-48809RH 0.25 mg
EUR 767

Rat Anti Human Hla Dr Monoclonal Antibody

DMABT-48811RH 5 ml
EUR 580

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody

abx413474-02mg 0.2 mg
EUR 565

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody

abx415437-025mg 0.25 mg
EUR 565

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody

abx415449-02mg 0.2 mg
EUR 565

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody

abx200524-100ug 100 ug
EUR 328

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody

abx140253-01mg 0.1 mg
EUR 370

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody

abx140231-01mg 0.1 mg
EUR 370

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody

abx140254-01mg 0.1 mg
EUR 370

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody

abx140257-01mg 0.1 mg
EUR 370

Anti-HLA-DR/DP Purified

11-239-C025 0.025 mg
EUR 99

Anti-HLA-DR/DP Purified

11-239-C100 0.1 mg
EUR 158

Anti-HLA-DR/DP Purified

11-240-C025 0.025 mg
EUR 99

Anti-HLA-DR/DP Purified

11-240-C100 0.1 mg
EUR 158

Anti-HLA-DR/DP Purified

11-296-C025 0.025 mg
EUR 99

Anti-HLA-DR/DP Purified

11-296-C100 0.1 mg
EUR 158

Anti-HLA-DR/DP Biotin

1B-296-C025 0.025 mg
EUR 122

Anti-HLA-DR/DP Biotin

1B-296-C100 0.1 mg
EUR 204

Anti-HLA-DR/DP FITC

1F-239-T025 25 tests
EUR 122

Anti-HLA-DR/DP FITC

1F-239-T100 100 tests
EUR 204

Anti-HLA-DR/DP FITC

1F-296-T025 25 tests
EUR 122

Anti-HLA-DR/DP FITC

1F-296-T100 100 tests
EUR 204

Anti-HLA-DR/DP PE

1P-239-T025 25 tests
EUR 140

Anti-HLA-DR/DP PE

1P-239-T100 100 tests
EUR 240

Anti-HLA-DR/DP PE

1P-296-T025 25 tests
EUR 140

Anti-HLA-DR/DP PE

1P-296-T100 100 tests
EUR 240

Anti-HLA-DR Alexa Fluor647

A6-690-T025 25 tests
EUR 154

Anti-HLA-DR Alexa Fluor647

A6-690-T100 100 tests
EUR 269

Anti-HLA-DR Alexa Fluor700

A7-474-T025 25 tests
EUR 154

Anti-HLA-DR Alexa Fluor700

A7-474-T100 100 tests
EUR 269

Anti-HLA-DR PE-DyLight594

T5-690-T025 25 tests
EUR 154

Anti-HLA-DR PE-DyLight594

T5-690-T100 100 tests
EUR 268

Anti-HLA-DR PE-Cy7

T7-690-T025 25 tests
EUR 154

Anti-HLA-DR PE-Cy7

T7-690-T100 100 tests
EUR 268

Anti-HLA-DR PE-Cy5

T8-690-T025 25 tests
EUR 140

Anti-HLA-DR PE-Cy5

T8-690-T100 100 tests
EUR 240

Anti-HLA-DR PerCP-Cy5.5

T9-690-T025 25 tests
EUR 196

Anti-HLA-DR PerCP-Cy5.5

T9-690-T100 100 tests
EUR 352

Anti-HLA-DR Pacific Blue

PB-474-T025 25 tests
EUR 154

Anti-HLA-DR Pacific Blue

PB-474-T100 100 tests
EUR 269

Anti-HLA-DR Pacific Blue

PB-690-T025 25 tests
EUR 154

Anti-HLA-DR Pacific Blue

PB-690-T100 100 tests
EUR 269

Anti-HLA-DR Pacific Orange

PO-690-T025 25 tests
EUR 154

Anti-HLA-DR Pacific Orange

PO-690-T100 100 tests
EUR 269

HLA-DR Antibody (FITC)

abx200525-100tests 100 tests
EUR 398

HLA-DR Antibody (Biotin)

abx200529-100ug 100 ug
EUR 384

HLA-DR Antibody (FITC)

abx134336-100Assays 100 Assays
EUR 439

HLA-DR Antibody (FITC)

abx134336-50Assays 50 Assays
EUR 342

HLA-DR+DP Antibody

abx140228-01mg 0.1 mg
EUR 356

HLA-DR+DP Antibody

abx140232-01mg 0.1 mg
EUR 356

HLA-DR+DP Antibody

abx140233-01mg 0.1 mg
EUR 356

HLA-DR Antibody (FITC)

abx140296-100tests 100 tests
EUR 425

HLA-DR Antibody (FITC)

abx140304-100tests 100 tests
EUR 425

HLA DR beta antibody

23015-100ul 100ul
EUR 390

HLA-DR Conjugated Antibody

C48982 100ul
EUR 397

HLA-DR/CD34

HLADRF34PE-50T 50 test
EUR 323

HLA-DR/CD3

HLADRF3PE1-50T 50 test
EUR 350.3

HLA-DR/CD8

HLADRF8PE1-50T 50 test
EUR 350.3

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (RPE)

abx413475-100tests 100 tests
EUR 592

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (FITC)

abx415435-01mg 0.1 mg
EUR 509

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (RPE)

abx415436-100tests 100 tests
EUR 592

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (PE)

abx200526-100tests 100 tests
EUR 453

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (PerCP)

abx200528-100tests 100 tests
EUR 453

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (PerCP)

abx140293-100tests 100 tests
EUR 481

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (PE)

abx140305-100tests 100 tests
EUR 481

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (PE)

abx140294-100tests 100 tests
EUR 481

Mouse Anti Human Hla Dr Monoclonal Antibody,RPE

DMABT-48807MH 100 TEST
EUR 715

Rat Anti Human Hla Dr Monoclonal Antibody,FITC

DMABT-48808RH 0.1 mg
EUR 663

Rat Anti Human Hla Dr Monoclonal Antibody,RPE

DMABT-48810RH 100 TEST
EUR 710

CD9 Antigen (CD9) Antibody (APC-C750)

abx200084-100tests 100 tests
EUR 996

Neprilysin / NEP (MME) Antibody (APC-C750)

abx200092-100tests 100 tests
EUR 648

Anti-HLA-DR Antibody [L243], PerCP-100Tests

QAB86-PCP-100Tests 100Tests
EUR 428

Anti-HLA-DR Antibody [L243], PerCP-25Tests

QAB86-PCP-25Tests 25Tests
EUR 225

Anti-HLA-DR Antibody [L243], PE-100Tests

QAB86-PE-100Tests 100Tests
EUR 251

Anti-HLA-DR Antibody [L243], PE-25Tests

QAB86-PE-25Tests 25Tests
EUR 141

Anti-HLA-DR Antibody [L243], PE-500Tests

QAB86-PE-500Tests 500Tests
EUR 893

Anti-HLA-DR Purified Low Endotoxin

12-690-C100 0.1 mg
EUR 167

Anti-HLA-DR/DP Alexa Fluor700

A7-296-T025 25 tests
EUR 154

Anti-HLA-DR/DP Alexa Fluor700

A7-296-T100 100 tests
EUR 269

Anti-HLA-DR/DP Pacific Blue

PB-296-T025 25 tests
EUR 154

Anti-HLA-DR/DP Pacific Blue

PB-296-T100 100 tests
EUR 269

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (CF-Blue)

abx200530-100tests 100 tests
EUR 481

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (OC-515)

abx200531-100tests 100 tests
EUR 467

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (PerCP-Cy5.5)

abx200533-100tests 100 tests
EUR 481

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (CF-Blue)

abx200534-100tests 100 tests
EUR 481

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (PerCP-Cy5.5)

abx200535-100tests 100 tests
EUR 773

HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DR) Antibody

20-abx134338
  • EUR 356.00
  • EUR 565.00
  • EUR 300.00
  • 100 ul
  • 200 ul
  • 50 ul

HLA-DR+DP Antibody (PE)

abx140298-100tests 100 tests
EUR 481

HLA-DR+DP Antibody (Biotin)

abx140300-01mg 0.1 mg
EUR 425

HLA-DR+DP Antibody (FITC)

abx140301-100tests 100 tests
EUR 425

HLA-DR+DP Antibody (FITC)

abx140302-100tests 100 tests
EUR 425

HLA-DR+DP Antibody (PE)

abx140297-100tests 100 tests
EUR 481

Anti-human HLA-DR Monoclonal Antibody Unconjugated, Flow Validated

FC00568 100µg, 500µg
EUR 114
Description: Mouse Monoclonal human HLA-DR Antibody Unconjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Mouse Anti Human Hla Dp Dq Dr Monoclonal Antibody

DMABT-48793MH 0.2 mg
EUR 741

Mouse Anti Human Hla Dp Dq Dr Monoclonal Antibody

DMABT-48795MH 0.2 mg
EUR 767

Mouse Anti Human Hla Dr Monoclonal Antibody,Azide Free

DMABT-48804MH 1 mg
EUR 1261

HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DR) Antibody (PE)

abx134337-100Assays 100 Assays
EUR 495

HLA Class II Histocompatibility Antigen, DR Alpha Chain (HLA-DR) Antibody (PE)

abx134337-50Assays 50 Assays
EUR 398

HLA-DR Antigens-Associated Invariant Chain (HLA-DR) Antibody (PE-DyLight 594)

abx140339-100tests 100 tests
EUR 523

Integrin Alpha-4 (CD49d) Antibody (APC-C750)

abx201084-100tests 100 tests
EUR 690

Anti-HLA-DR Antibody [L243], Qfluor 710-100Tests

QAB86-QF710-100Tests 100Tests
EUR 352

Anti-HLA-DR Antibody [L243], Qfluor 710-25Tests

QAB86-QF710-25Tests 25Tests
EUR 200

Anti-HLA-DP/-DR (MHC II) Monoclonal Antibody

M00487 100ug/vial
EUR 397
Description: Anti-HLA-DP/-DR (MHC II) Antibody

Mouse IgG1 Isotype Control (APC-C750)

abx200571-50ug 50 ug
EUR 787

Mouse IgG2a Isotype Control (APC-C750)

abx200579-50ug 50 ug
EUR 787

Anti-HLA-DP/ HLA-DR Antibody Clone Bra-14, Unconjugated-100ug

3115-MSM2-P1 100ug
EUR 428

Anti-HLA-G APC

1A-292-C025 0.025 mg
EUR 186

Anti-HLA-G APC

1A-292-C100 0.1 mg
EUR 373

HLA-DR / CD3 Antibody (FITC, PE)

abx200620-50tests 50 tests
EUR 425

HLA-DR / CD8 Antibody (FITC, PE)

abx200621-50tests 50 tests
EUR 425

HLA-DR / CD34 Antibody (FITC, PE)

abx200622-50tests 50 tests
EUR 425

Anti-human HLA-DR Monoclonal Antibody Biotin Conjugated, Flow Validated

FC00568-Biotin 100µg
EUR 233
Description: Mouse Monoclonal human HLA-DR Antibody Biotin Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human HLA-DR Monoclonal Antibody FITC Conjugated, Flow Validated

FC00568-FITC 25 Tests, 100 Tests, 200 Tests
EUR 137
Description: Mouse Monoclonal human HLA-DR Antibody FITC Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human HLA-DR Monoclonal Antibody PE Conjugated, Flow Validated

FC00568-PE 25 Tests, 100 Tests, 200 Tests
EUR 153
Description: Mouse Monoclonal human HLA-DR Antibody PE Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Anti-human HLA-DR Monoclonal Antibody PerCP Conjugated, Flow Validated

FC00568-PerCP 100 Test, 200 Tests
EUR 342
Description: Mouse Monoclonal human HLA-DR Antibody PerCP Conjugated, Flow Validated. Validated in Flow Cytometry and tested in Human.

Mouse Anti Human Hla Dp Dq Dr Monoclonal Antibody,FITC

DMABT-48792MH 0.1 mg
EUR 663

Mouse Anti Human Hla Dp Dq Dr Monoclonal Antibody,FITC

DMABT-48794MH 0.1 mg
EUR 663

Our results show that variability may inhibit HBV viral peptide-MHC binding, required to initiate the cascade of immunological responses to infection.